Answer:
Different type of mutation cause phenotypic change by addition,deletion or substitution of amino acids in an open reading frame of mRNA.
Step-by-step explanation:
Mutation can be defined as alteration in nucleotide sequence of target DNA molecule.Which force the mutated DNA to undergo phenotypic change resulting in the formation of abnormal protein or disease causing protein.
Foe example When the β6 glutamic acid of hemoglobin is replaced by amino acid valine it result in the sickling of red blood cells that ultimately leads to the development of sickle cell anemia, a life threatening disease.