Question

CCR5 is a cell surface receptor protein of white blood cells that attracts them to specific tissue and organs to elicit an immune response. It is also the receptor to which R5 strains of HIV bind to and enter T cells. Between 5–14% of people from Northern European descent possess an allele known as CCR5-Δ32. In this allele, a 32 base pair section of the gene has been deleted. What phenotype would you predict for people carrying the CCR5-Δ32 allele?

Answer 1

resistant to R5 stain of HIV

Step-by-step explanation:

More information is necessary to make a complete prediction, but if the recognition site of the R5 strain of HIV is at or dowstream of the deletion that person should be resistant (HIV could not enter its white blood cells). That would be because the 10 aminoacids coded by the 32 baise pairs are missing, and since is a frame shifting mutation (not multiple of 3 like 30 or 33) all aminoacids dowstream would be changed.