Answer:
The correct answer is a) when antibiotics are used indiscriminately
Step-by-step explanation:
WHO said that the indiscriminate use of antibiotics is leading to the development of drug-resistant bacteria. Antibiotics do not only kill pathogenic bacteria but also harmful to natural microbiota of human which is helpful for good human health.
Use of antibiotics without prescription, overuse or irregular use is leading to antibiotic-resistant bacteria and these antibiotic-resistant bacteria can transfer the antibiotic-resistant genes to other bacteria through horizontal gene transfer.
Use of antibiotics for the growth of chickens and other animals is also a great cause of concern that is leading to many antibiotic-resistant bacteria. Therefore when antibiotics are used indiscriminately drug resistance occurs.