Question

Summarize how Crigler-Najjar syndrome affects the human body as a disorder progress

Answer 1

Crigler-Najjar syndrome is a genetic disorder that affects the liver's ability to process bilirubin, leading to high levels of bilirubin in the blood. It can cause symptoms such as jaundice and neurological problems.

Step-by-step explanation:

Crigler-Najjar syndrome is a genetic disorder that affects the liver's ability to process a pigment called bilirubin. In this disorder, there is a deficiency in the enzyme UDP glucuronyl transferase, which is responsible for converting bilirubin into a form that can be excreted from the body. As a result, bilirubin builds up in the bloodstream, leading to a condition called hyperbilirubinemia.

In Type I Crigler-Najjar syndrome, there is a complete absence of UDP glucuronyl transferase activity, leading to extremely high levels of bilirubin in the blood. This can cause severe symptoms such as jaundice, lethargy, and neurological problems. Type II Crigler-Najjar syndrome, on the other hand, still allows some bilirubin to be converted, but not enough to prevent buildup in the blood.

Answer 2

The type 1 Kernicterus, of the Crigler-Najjar syndrome can cause death and the second type is less serious than first type and causes jaundice in new borns.

Step-by-step explanation:

The syndrome of Crigler- Najjar is caused by the mutation of the gene UGT1A1. This gene carries information about the production of uridine-disphospate, liver enzyme that helps in excreting bilirubin from human body. The absence of this gene causes failed excretion of bilirubin leading to high increase of it in the body.

The excessive bilirubin crosses the blood barrier of the brain and affects it causing this syndrome. The 1st type, Kernicterus is severe and can cause death but the second one is less acute and cause jaundice in newborns.