Question

The oxidation of pyruvate is not the only process that generates acetyl-CoA. In particular, fatty acids are broken down through oxidation, generating a great deal of acetyl-CoA, which can also enter the TCA cycle to generate high energy molecules. Is there a difference between between the TCA cycle using acetyl-CoA generated from fatty acid oxidation compared to that generated from carbohydrate oxidation?

A. The concentration of malate increases when reacting with acetyl-CoA derived from a fatty acid,
B. A molecule of acetyl-CoA derived from a fatty acid generates more FADH2 than acetyl-CoA from
C. A molecule of acetyl-CoA derived from a carbohydrate generates more NADH than acetyl-CoA but not when reacting with acetyl-CoA derived from a carbohydrate. WI derived from a carbohydrate derived from a fatty acid.
D. There is no difference in the TCA cycle, regardless of the source of acetyl-CoA.

Answer 1

The correct answer is D. There is no difference in the TCA cycle,regardless of source of acetyl CoA.

Step-by-step explanation:

Acetyl CoA is the central metabolite of aerobic respiration.Acetyl CoA is generated from both decarboxylation of pyruvate and from the beta oxidation of fatty acid in mitochondrial matrix.

In both cases the generated Acetyl CoA molecule is same but it comes from different source.

If the Acetyl CoA generated from beta oxidation of fatty acid enter into the TCA cycle it will generate same molecules of NADP and FADH2 as that of Acetyl CoA generated from carbohydrate metabolism