Question

Which of the following cellular environments is conducive to the formation of disulfide bonds within or between proteins? Choose all that apply. Which of the following cellular environments is conducive to the formation of disulfide bonds within or between proteins? Choose all that apply. Rough ER Cytosol Nucleus Mitochondria

Answer 1

Rough endoplasmic reticulum and Mitochondria.

Step-by-step explanation:

Disulfide bonds are known as covalent bonds. They are formed by the oxidation of 2 cysteines and these bonds can provide stability to proteins. These bonds mainly formed in intermembrane space of mitochondria and cellular compartments outside the cytoplasm endoplasmic reticulum. Both of these organelles present in an oxidation state providing an atmosphere for disulfide bond formation.

Cytoplasm and Nuclei mostly exit in reducing state because of the existence of disulfide reductase which is reducing the disulfide bonds between the cysteine residue to thiolate state. So, the disulfide bond formation will not happen.