Final answer:
The skin and mucous membranes form a selective barrier to protect the body from pathogens.
Step-by-step explanation:
The organ and system that protect the body by forming a selective barrier are the skin and mucous membranes. The skin is the body's largest organ and forms a physical barrier between the body and the outside world. It is difficult for pathogens to get through the tough, waterproof outer layer of the skin. Mucous membranes, such as those in the respiratory and gastrointestinal tracts, also provide a barrier to pathogens and facilitate their removal.