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Why were diseases the greatest threat to the existence of American Indians?

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They probably couldn’t have had any kind of medication that could prevent, heal, or make a disease go away. If it was a disease brought by Europeans, they would be at a greater threat since they’ve never encountered it before and have no immunity to it.
User Vser
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Answer:

Because the diseases were unknown to them, they spread easily and could kill off thousands of their kind.

User JFCorleone
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