Question

What would most likely occur to nuclear-cytoplasmic shuttling if the intrinsic GTPase activity of RAN was slowed down by 50%?

None of the answers are likely
All of the answers are likely
Importin beta would not release from RAN in the cytoplasm and nuclear import would slow down
RAN would not bind exportin and proteins would accumulate in the nucleus
RAN would not bind to importin beta and protein cargo in the nucleus would not release

Answer 1

All of the answers are likely

Step-by-step explanation:

• The active form of RAN is in the GTPase form i.e. RAN-GTP
• When this form of ran is slowed down by 50%, the RAN will not be able to bind importins or exportins as efficiently as it usually would.
• a slowed down version of RAN-GTP means that it cannot release importins, exportins or cargo proteins as efficiently either.
• In conclusion all aspects of nuclear- cytoplasmic shuttling are slowed down