Question

What can a deficiency of growth hormone during bone formation cause? inadequate calcification of bone decreased epiphyseal plate activity decreased osteoclast activity increased osteoclast activity

Answer 1

A deficiency of growth hormone (GH) during bone formation can lead to decreased epiphyseal plate activity, resulting in reduced bone length and potentially causing conditions like pituitary dwarfism in children.

Step-by-step explanation:

A deficiency of growth hormone (GH) during bone formation can cause decreased epiphyseal plate activity, which in turn can lead to inadequate bone growth in length. Growth hormone is essential for stimulating bone growth and maintaining osseous tissue. It enhances the mineralization of bones, stimulates the production of bone matrix by osteoblasts, and contributes to increasing bone density. A lack of GH during childhood can result in pituitary dwarfism, leading to reduced growth and a proportional but smaller stature. The epiphyseal plates are responsible for longitudinal bone growth, and a decrease in their activity due to GH deficiency would directly impact the lengthening of bones during development.

Answer 2

Decreased osteoclast activity

Step-by-step explanation:

Growth hormone (GH) plays a significant role in the growth and bone metabolism, and in bone remodeling which is the process of bone formation by osteoblasts and bone resorption by osteoclasts. GH stimulates osteoblast proliferation and activity, promoting bone formation, as well as bone resorption by osteoclast. For that reason, the deficiency of GH causes a reduction in bone remodeling activity and bone mineral density, and limits bone growth and the accumulation of bone mass.