Question

Consider phosphofructokinase, which statement is true? Group of answer choices

None of the above.
High ATP inhibits the enzyme; fructose-2,6-bisphosphate activates the enzyme.
Low ATP activates the enzyme; fructose -2,6-bisphosphate inhibits the enzyme.
High ATP activates the enzyme; fructose -2,6-bisphosphate inhibits the enzyme.
Fructose -2,6-bisphosphate and ATP inhibit the enzyme.

Answer 1

High ATP inhibits the enzyme; fructose-2,6-bisphosphate activates the enzyme.

Step-by-step explanation:

PFK-1 inhibitors are ATP and Citrate which is an intermediate metabolite of the aerobic cycle while the activators responsible for reversing such inhibition caused by ATP are ADP, AMP and Fructose -2,6-bisphosphate. The lats one is a powerful activator of PFK-1 but in the liver.