Hello there!
The point (2,-3) would lay in quadrant IV, or 4.
Basically:
Points that are (x, y) or positive x and positive y ay in quadrant 1, or I.
Points that are (-x, y) or negative x and positive y lay in quadrant 2, or II.
Points that are (-x, -y) or negative x and negative y usually lay in quadrant 3, or III.
Points that are (x, -y) or positive x and negative y usually lay in quadrant 4, or IV.
I hope this was helpful! Have a great rest of your day :)