Answer:
The correct answer is option - only second and third scenarios are plausible.
Step-by-step explanation:
A mutation that removes or eliminates the activity of the enzyme that is responsible or involved in synthesis of the porphyrin which cause pathogenic condition called anemia.
A mutation that allows that cause normal fetal hemoglobin to keep on producing into adulthood would enhances symptoms of sickle cell that is also a pathogenic condition.
Thus, the correct answer is option - only second and third scenarios are plausible.