Answer:
Unexpected, related or possibly related to the research, suggests the research puts subjects or others at greater risk
Step-by-step explanation:
The Office for Human Research Protections "defines" an unanticipated problem as unexpected in terms of nature, severity, or frequency given the research procedures and the characteristics of the subject population being studied. This is related or possibly related to the research and suggests that the research sets subjects at a greater risk of harm.