In principle, at least one way to increase the concentration of G6P is to drive the equilibrium to the right by increasing the intracellular concentrations of Pi and/or glucose. Assuming a fixed concentration of Pi at 5.0 mM, how high would be the intracellular concentration of glucose have to be to give an equilibrium concentration of glucose−6−phosphate of 0.25 mM (the normal physiological concentration)? Would this route be reasonable, given the maximum solubility of glucose is less than 1 M?