Question

JY is a 58 year old male who was hospitalized for a total knee replacement. He was given unfractionated heparin and developed heparin-induced thrombocytopenia (HIT). Argatroban was ordered at a dose of 2 mcg/kg/min. The pharmacy mixes a concentration of 100 mg argatroban in 250 mL of DSW. JY weighs 85 kg. How many mL/hour should the nurse infuse to provide the dose? Round to the nearest whole number. .

Answer 1

The nurse infuse
`26ml/hr` to provide the dose.

Explanation:

Argatroban was ordered at a dose of 2 mcg/kg/min.

JY weighs 85 kg.

So, Argatroban was ordered=
`2 * 85`

=
`170mcg/min.`

Convert the dose in mg/hr

1 hr = 60 minutes and 1 mg = 1000 mcg

So, Dose in ml/hr =
`170 * (60)/(1000)`

=
`10.2 mg/hr`

Now to find in 250 mL of DSW. JY weighs 85 kg. How many mL/hour should the nurse infuse to provide the dose?

The nurse infuse to provide the dose =
`\text{Dose ordered} * \frac{\text{volume available}}{\text{Dose available}}`

The nurse infuse to provide the dose =
`10.2 mg/hr * (250 ml)/(100 mg)`

The nurse infuse to provide the dose =
`26ml/hr`

Hence The nurse infuse
`26ml/hr` to provide the dose.