Question

If the pediatric dosage of chlorothiazide (DIURIL) is 10 to 20

mg/kg of body weight per day in a single dose or two divided doses,
not to exceed 375 mg/day, calculate the daily dosage range of an
oral suspension containing 250 mg chlorothiazide per 5 mL that
should be administered to a 48-lb child.

Answer 1

To calculate the daily dosage range of chlorothiazide for a 48-lb child, convert the weight to kilograms and use the pediatric dosage recommendation of 10 to 20 mg/kg per day.

Step-by-step explanation:

To calculate the daily dosage range of an oral suspension containing 250 mg chlorothiazide per 5 mL for a 48-lb child, we need to convert the weight from pounds to kilograms. 48 lbs is equal to 21.8 kilograms.

Now, we can calculate the dosage range using the pediatric dosage recommendation of 10 to 20 mg/kg per day. For a 48-lb child, the dosage range would be:

1. 10 mg/kg x 21.8 kg = 218 mg/day
2. 20 mg/kg x 21.8 kg = 436 mg/day

Therefore, the daily dosage range for the 48-lb child would be 218 mg to 436 mg of chlorothiazide per day.

Answer 2

The daily dosage range of an oral suspension containing 250mg of chlorothiazide per 5mL that should be administered to a 48lb child is 4.35 to 7.5mL.

Step-by-step explanation:

1. The first thing to do is to convert the child's weight's units from pounds to kilograms: 48lb*(0.4536kg/lb) = 21.77kg
2. Then we calculate the lower and upper limits of chlorothiazide for this child: 10mg/kg*21.77kg = 217.7mg, and 20mg/kg*21.77kg = 435.46mg. We have to remember that he can't take more than 375mg/day.
3. The oral suspension's concentration is: 250mg/5mL. To calculate the daily dosage range of the suspension for this child, we use two "rules of three"

• x(min) = (217.7mg*5mL)/(250mg) = 4.35mL
• x(max) = (375mg*5mL)/250mg) = 7.5mL