Question

In a hemoglobin variant known as hemoglobin Kansas, an Asparaginein

the beta chain is replaced by a Threonine. This results in
thedisruption of a hydrogen bond that normally stabilizes the
R-stateof hemoglobin. Which statement is FALSE regarding the effect
thisamino acid change has on the ability of hemoglobin Kansas to
bindoxygen?

a. Inhemoglobin Kansas, there is an increase in the amount of
R-stateand a decrease in the amount of T-state.

b. In hemoglobinKansas, there is a decrease in the amount of
R-state and anincrease in the amount of T-state.

c. The R-state inhemoglobin Kansas is less stable than
normal.

d. The presence ofless oxy-Hb in hemoglobin Kansas indicates this
type of Hb has alower affinity for oxygen.

e. The p50 forhemoglobin Kansas is higher than normal.

Answer 1

The false statement is option a.

Step-by-step explanation:

If there occurs a disruption of a hydrogen bond, which usually stabilizes the R-state of hemoglobin, there is not likely to be an elevation in the concentration of R-state due to the unsteadiness of the hydrogen bond. The R-state would either remain constant or will get slow down.

Thus, the statement, that is, in hemoglobin Kansas, there is an elevation in the concentration of R-state and a reduction in the concentration of T-state is false.