Question

A scientist is attempting to create a treatment for asthma. She knows that in people with asthma, their airways can become inflamed, or swollen, making it difficult to breathe. She knows that there are many genes responsible for this inflammation. She asks her team for ideas on how to treat asthma. You think RNA interference would work. Explain to her what RNA interference would do and the effect it would have on a patient with asthma.

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Answer 1

RNA interference is the process of silencing the specific sequences of mRNA through siRNA. RNA interference process can be used to treat many diseases.

Treating asthma is the new approach to treat it through gene silencing as some genes are responsible for causing inflammation and swelling of the airways or respiratory tract.

RNAi to treat the diseases are very specific as the siRNA forms RISC which binds to the mRNA to slice the gene and deactivate the functioning of the gene.