Answer:
The Spanish contact affected mainly due to the fact they wanted to convert American Indians into Christianity, even though Spanish manage to create bonds (marriage) with the Natives, it was not a good relationship for everyone. Compared to the French that had a friendlier approach with the Indians. Overall Spain tried to find a balance between being strict but still remaining passive with the Native.
With the settlement of ships along the Barrier Islands, Spain began missions in order to continue promoting Christianity.
Hernando de Soto started conquering South America and made his way up north, in which he brought ships to Florida, South Carolina and even reached the Mississippi River. His main objective was to find gold.