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In humans, albinism is caused by loss-of-function mutations in genes involved in the synthesis of melanin, the dark pigment in skin. Only people homozygous for a loss-of-function allele (genotype aa) have the albino phenotype. In Americans of northern European ancestry, albino individuals are present at a frequency of about 1 in 10,000 (or 0.0001). Assuming that genotypes are in Hardy−Weinberg equilibrium, what is the predicted frequency of Caucasians in the United States who carry a single allele for albinism?

User Koedlt
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Answer:

Thus, the predicted frequency of Caucasians in the U.S. who carry a single albino allele is 0.0198.

User Castis
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