Question

DNA damage repair by non-homologous end joining (NHEJ)

a. occurs during gene conversion.
b. is responsible for the repair of O6meG adducts.
c. is absent in Xeroderma pigmentosum (XP)
d. result in the loss of genetic information.
e. repair spontaneous DNA depurination.

Answer 1

D. result in the loss of genetic information.

Step-by-step explanation:

Ligation of broken DNA ends during non-homologous end joining (NHEJ) causes loss of genetic information.

Cellular nucleases are the enzymes that degrade the nucleotides at the breakage site. The loss of nucleotides results in the loss of part of or whole gene/s.

The process of NHEJ does not need a template and hence, can occur at any stage of the cell cycle. Here, imprecise joining and cellular nucleases during non-homologous end joining (NHEJ) result in the loss of nucleotides.