You Are going to first identify which numbers are similar to another.
-3, -18
6x, -22x
Start with the variables: 6x -22x
Which is -16x
Next combine the other numbers: -3-18
Which is -21
Finally you put together your 2 Answers together: -16x-21 or -21-16x
Hope this helps. You will use the sale method when combining like terms with an equal sign and multiple numbers and variables.