Question

What sequence of enzymes allows for the synthesis of glycogen from glucose-6-phosphate?

a. UDP-glucose pyrophosphorylase, phosphoglucomutase, glycogen synthase, amylo-(1,4α1,6)-transglycosylase

b. phosphoglucomutase, UDP-glucose pyrophosphorylase, amylo-(1,4α1,6)-transglycosylase, glycogen phosphorylase

c. phosphoglucomutase, amylo-(1,4α1,6)-transglycosylase, UDP-glucose pyrophosphorylase, glycogen synthase

d. UDP-glucose pyrophosphorylase, phosphoglucomutase, amylo-(1,4α1,6)-transglycosylase, glycogen synthase

e. phosphoglucomutase, UDP-glucose pyrophosphorylase, glycogen synthase, amylo-(1,4α1,6)-transglycosylase

Answer 1

The answer is (e) : phosphoglucomutase, UDP-glucose pyrophosphorylase, glycogen synthase then amylo-(1,4-1,6)-transglycosylase.

Step-by-step explanation:

Phosphoglucomutase: Convert glucose-6-phosphate to glucose-1-phosphate.

UDP-glucose pyrophosphorylase: Form UDP-glucose from glucose-1-phosphate.

Glycogen synthase: Add the new glucose from UDP-glucose to the growing glycogen chain.

Amylo-(1,4-1,6)-transglycosylase: This is a branching enzyme, it initiates formation of branches evolving from the main chain.