Answer:
Tertiary structure
Step-by-step explanation:
The tertiary structure of a protein includes the overall three-dimensional arrangement of all the atoms of a protein. The amino acid residue located far apart from each other in a protein and have different secondary structures interact and determine the overall folding pattern of the proteins.
Therefore, when any condition such as mad-cow disease causes misfolding of protein, it affects the tertiary structure of the proteins since the overall folding pattern of the protein reflects its tertiary structure.