Answer: A. ...nevertheless, Rainsford could not quiet his brain with the opiate of sleep. He lay, eyes wide open.
Explanation: Agitation or anxiety often result in lack of sleep or poor quality of sleep. The other options given do not depict agitation as clearly, for example, in Option B, he may be agitated by the stuck door, but his following action of going to and looking out of the window, does not portray his agitation.