Answer:
receptor down-regulation
Step-by-step explanation:
Downregulation is a control mechanism by which a cell decreases the amount of a cellular component, such as RNA or protein, in response to an external variable. In contrast, a reactive increase of a cellular component is called upregulation. An example of downregulation occurs when insulin binds to its receptor and the complex is endocyted in the cell in response to hormonal signaling.