Question

N-acetylcysteine Intravenously: Loading dose: 150 mg/kg IV; mix in 200 mL of 5% dextrose in water (D5W) and infuse continuously over 1 hour. What is the loading dose of N-acetylcysteine? (How many milligrams are added to the bag?) Patients weight is 58 kg.

Answer 1

The loading dose of N-acetylcysteine is 8,700 mg (150 mg per 55 kilograms).

The complete cycle of treatment with N-acetylcysteine comprises 3 consecutive intravenous infusions, distributed as follows:

1 infusion: Initial dose of 150mg / kg of body weight in 200 ml of solution to pass in one hour.

2 infusion: 50 mg / k of weight in 500 ml of solution to pass in 4 hours

3 infusion: 100mg / kg of weight in 1000ml to pass in the following 16 hours.