Question

When trypsinogen, chymotrypsinogen and procarboxypepdidase are prematurely activated in the pancreas they can digest pancreatic proteins and produce pancreatitis.

a. True
b. False

Answer 1

It is true that if trypsinogen, chymotrypsinogen, and procarboxypepdidase are activated too early in the pancreas, they can lead to the digestion of pancreatic proteins and cause pancreatitis.

Step-by-step explanation:

It is true that when trypsinogen, chymotrypsinogen, and procarboxypepdidase are prematurely activated in the pancreas, they can digest pancreatic proteins and produce pancreatitis. These enzymes are meant to be activated in the small intestine, specifically in the duodenum, to aid in protein digestion. The pancreas produces these enzymes as inactive zymogens to prevent self-digestion. Once secreted into the duodenum, enteropeptidase, an intestinal brush border enzyme, activates trypsinogen to trypsin, which in turn activates chymotrypsinogen to chymotrypsin and procarboxypeptidase to carboxypeptidase. These activated enzymes then break down proteins into smaller peptides and amino acids. If prematurely activated within the pancreas, they can begin to digest the pancreas itself, leading to inflammation and pancreatitis.

Answer 2

a. True

Step-by-step explanation:

Pancreatitis, a disease which involves the inflammation of the pancreas. Pancreatic damage can happen when digestive enzymes become activated before being released into small intestine and the digestive enzymes attack pancreas.

Trypsinogen, chymotrypsinogen and procarboxypepdidase are precursor forms of trypsin, chymotrypsin and carboxypepdidase.

If they are prematurely activated, they will make these enzymes which can degrade/ digest the pancreatic proteins.