Question

The mechanism under the therapeutio effect of lovastatin is:

A. inhbiting COx
B. inhibiting HMG-CoA reductase
C. inhibiting thrombin
D. inhibiting Na-"K" ATPase

Answer 1

(B). inhibiting HMG-CoA reductase.

Step-by-step explanation:

Lovastatin is a drug, which is used to reduce risk for cardiovascular diseases and to reduce level of cholesterol in blood.

It works by inhibiting HMG-CoA reductase (3-hydroxy-3-methylglutaryl-coenzyme A reductase) enzyme, required for the formation of mevalonate from HMG-CoA.

Mevalonate is building block for the biosynthesis of cholesterol. Hence, lovastatin inhibits cholesterol production by inhibiting synthesis of mevalonate.

Thus, the correct answer is option (B).