Question

Compare and contrast the two thienopyridines: clopidogrel and parasugrel. Why would one drug be better suited for the clinic than another?

Answer 1

Clopidogrel is a thienopyridine that belongs to the class of drug
`P2Y_(12)` ADP receptors. Clopidogrel inhibits the platelets aggregation and activation. This drug can reduce the rate of myocardial infarction in the patients. The chances of bleeding increases if the drug is coadministered with serotonin.

Parasugrel is a thienopyridine that belongs to the class of drug
`P2Y_(21)` ADP receptors. Parasugrel inhibits the platelets activation by the irreversible binding with its receptor. This drug can reduce the rate thrombotic cardiovascular events. The chances of bleeding increases if the drug is coadministered with warfarin.

Parasugrel is better suited than clopidegrol in case of stent thrombosis because this drug works faster and can easily be absorbed in the small intestine.