Question

From the list below, which event leads to activation of NF-κB?

Question 1 options:

A)

selectin binding

B)

S-Lex interactions

C)

integrin activation

D)

TLR activation

E)

ICAM activation

Answer 1

(D) . TLR activation.

Step-by-step explanation:

Nuclear factor kappa light chain enhancer of activated B cells (NF-κB) represents a protein complex, which plays various roles in activation of adaptive and innate immune response.

TLRs (toll-like receptors) are specific pattern recognition molecules found in pathogens that triggers immune responses. TLR activation stimulates activation of NF-κB signalling by triggering a downstream signaling cascades.

Activation of NF-κB signalling leads to upregulation of various pro-inflammatory substances or cytokines.

Thus, the correct answer is option (D).