Final answer:
Francesco Redi's experiments were with raw meat and flies, contrasting spontaneous generation by showing that maggots come from flies, not directly from the meat. Louis Pasteur's work with broth in swan-neck flasks further refuted spontaneous generation by proving that microorganisms are airborne and not spontaneously generated.
Step-by-step explanation:
The designs of Pasteur’s and Redi’s experiments were different in that Francesco Redi conducted experiments using raw meat to challenge the theory of spontaneous generation, while Louis Pasteur utilized broth in his famous swan-neck flask experiments. Redi demonstrated that preventing flies from accessing meat precluded the development of maggots, thereby disputing the spontaneous generation of maggots from meat.
The ground-breaking work of Pasteur further refuted spontaneous generation by showing that life does not arise from sterile nutrient solutions unless introduced to contaminants from the air. His swan-neck flasks allowed air inside while blocking microbial entry, proving that microorganisms are airborne and not formed spontaneously.