Answer:
I guess that we want to find the displacement between Andrew's house and his uncle's house.
Assuming that he drove in a straight line, we can use the relationship:
Distance = Speed*Time.
We know that he drove for 6 hours, and the speed was 48 miles per hour, then the distance will be:
distance = 6h*48mi/h = 288 mi
This means that the total distance is 288 miles.