Question

Make a claim about how PDC deficiency affects the amount of NADH produced by glycolysis AND the amount of NADH produced by the Krebs (citric acid) cycle in a cell. Provide reasoning to support your claims based on the position of the PDC -catalyzed reaction in the sequence of the cellular respiration pathway.

Answer 1

Glycolysis: No change - glycolysis continues PFC is not needed, glycolysis occurs before conversation of pyruvate to acetyl - CoA

Krebs Cycle: Decrease - krebs cycle greatly slowed / deceased if there isn't acetyl - CoA; Occurs after conversation of pyruvate to acetyl - CoA

Step-by-step explanation:

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