Final answer:
Blood returning from the lungs via a pulmonary vein enters the heart through the left atrium.
Step-by-step explanation:
Blood returning to the mammalian heart in a pulmonary vein first drains into the left atrium (E). The right atrium receives blood from the systemic circuit that is low in oxygen, which then moves to the right ventricle and is pumped to the lungs via the pulmonary artery. The oxygenated blood from the lungs then returns through the pulmonary veins and enters the left atrium. The pulmonary circulation involves the movement of blood from the right atrium, to the right ventricle, to the lungs, and back to the heart's left atrium.