Answer:
All of these choices are correct.
Step-by-step explanation:
Histone modification can be defined as a type of gene expression regulation. It refers to covalent post-translational modifications of histon tail proteins such as methylation, phosphorylation, acetylation, ubiquitylation, and sumoylation. As a consequence of modifications, chromatin structure might be changed, into active regions of euchromatin, (active transcription), or heterochromatin regions (inactive transcription).
Modification might be due to response to the environment, are heritable and are called epigenetic control.