Question

If a mutation occurred in the cadherin gene so that the cytoplasmic domain no longer attached to the cytoskeleton, which of the following would occur?

A. Cadherins in desmosomes would no longer be anchored to intermediate filaments
B. Cadherins in adherens junctions would no longer be anchored to microtubules
C. Cadherins in hemidesmosomes would no longer be anchored to intermediate filaments
D. Cadherins in desmosomes would no longer be anchored to microfilaments

Answer 1

A. Cadherins in desmosomes would no longer be anchored to intermediate filaments

Step-by-step explanation:

Cadherins are Ca dependent molecules (proteins) that are involved in cell-cell adhesion (they are type of cell adhesion molecule-CAM). Cadherins are composed of: a small cytoplasmic component, a transmembrane component, and the extra-cellular part.

There are types of cadherins called desmosomal cadherins which are involved in the formation of desmosomes (structure for cell-cell adhesion) and they bind to linker proteins and keratin intermediate filaments.