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What determines the sequence of sugar addition to glycoproteins traveling through the Golgi complex?

A) Nothing - the sequence is random.
B) the spatial arrangement of specific glycosyltransferases that contact proteins as they pass through the Golgi complex
C) the concentration of sugars in the Golgi complex
D) the sequence of sugars in the Golgi complex
E) the sequence of nucleotides in the Golgi complex

User Bsn
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2 Answers

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Final answer:

The sequence of sugar addition to glycoproteins in the Golgi complex is determined by the specific placement of glycosyltransferases within the Golgi.

Step-by-step explanation:

The sequence of sugar addition to glycoproteins traveling through the Golgi complex is determined by B) the spatial arrangement of specific glycosyltransferases that contact proteins as they pass through the Golgi complex. These enzymes are positioned in such a way within the Golgi that they sequentially add sugars to the oligosaccharide chains on the glycoproteins as they move from the cis face to the trans face of the Golgi apparatus. The initial part of the glycoprotein synthesis begins in the rough endoplasmic reticulum (RER) with the creation of a core glycoside and is then completed with terminal glycosylation in the Golgi, where final modifications are made before they are dispatched to their final destinations.

User Marcusds
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B. The spatial arrangement of specific glycosyltransferases that contact proteins as they pass through the Golgi complex
User Sergei Rogovtcev
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