Question

The induced fit model of enzyme activity suggests which of the following?

A) The binding of substrate depends on the conformation of the active site.
B) The binding of an activator alter the conformation of the active site to bind products more tightly.
C) The binding of substrate changes the conformation of the active site to bind substrate more tightly.
D) The binding of a competitive inhibitor changes the shape of the active site to bind substrate less tightly.

Answer 1

Answer;

C) The binding of substrate changes the conformation of the active site to bind substrate more tightly.

Explanation;

• Induced fit theory is the idea that the substrate plays a role in determining the final shape of the enzyme and that the enzyme is partially flexible. Other molecules may be too small to induce the proper alignment and therefore cannot react.
• Only the proper substrate is capable of inducing the proper alignment of the active site.
• Induced fit model asserts that when the active site on the enzymes makes contact with the proper substrate, the enzyme molds itself to the shape of the molecule.