Answer:
No, it was not possible to have done an effective counterattack or promote a better resistance than the one they made it. The Native Americans did what they could to fight against the European encroachment.
Step-by-step explanation:
It's hard to consider historical points based on a hypothetical approach. However, in this case, it's relatively easy to consider the facts. You know, Europeans had more than just modern weapons. Beyond the shotguns, they brought with them, inside their bodies, a different and mortal weapon: germs and bacterias. Against this biological war, that it was involuntary by the European part (just happened), the Native Americans saw themselves vulnerable to diseases they didn't know how to heal.