Answer #1, not a cause of Protestant Reformation:
Answer #2, not a consequence of Protestant Reformation:
Step-by-step explanation:
The Thirty Years' War was one of the Wars of Religion that followed as a consequence of the Protestant Reformation. The Protestant Reformation is usually dated as beginning in 1517 with Martin Luther's posting of his 95 Theses concerning the sale of indulgences. The Thirty Years' War was fought a century after that, from 1618-1648.
The Columbian Exchange is the name given to transfer of plants, animals, culture, people, ideas and more between Europe, the American continents, and West Africa, in the 15th and 16th centuries. It is named after Christopher Columbus, who was credited with "discovering" the lands of the Western Hemisphere with his voyages beginning in 1492. The Columbian Exchange happened around the same time as the Protestant Reformation and its aftermath were occurring in Europe, but the two were not related events.