The tumor suppressors allele is analogous to the brake pedal in a vehicle while cyclins are like the gas pedal. The tumor supressors regulate, negatively, the replication of cells. If the tumor supressor is mutated, this is analogous to the brake pedals of the vehicle being broken, This means that if two are broken, then the vehicle will be unable to stop and will continue moving. This same way, if tumor suppressors are mutated, the replication of cells will continue unregulated and casue a tumor.