President Thomas Jefferson defended that the Native American needed respect, since he considered them a noble race. He believed that if they made the Natives adopt the European-style, including the agriculture and way of living, they would be able to a fast progress from the "savagery" to "civilization".
As president he saw the need of expanding borders into the Native American territories in a pacific way so it wouldn't turn out in war. His first plan was to make the Native pregnant women give up their beliefs and lifestyle introducing instead the European's. He expected to assimilate Natives into a market-based agricultural society stripping them of their self-sufficiency, turning them dependent on comercial trading with the Americans. In that way, the Natives would probably give up the land that they wouldn't part with in any other way.
Jefferson kept the emphasis of the necessity to treat the Indian tribes in the most conciliatory manner. He believed in avoiding war and their probable extermination by forcing them out and relocating them to the west if there were any resistance. For him, it was the only way to ensure their survival. Jefferson made a deal with Georgia that the U.S. army would help to forcefully expel the tribes if they released their legal claim to discovery in lands to west. This deal was violating an already existing treaty the tribes had with the government that used to guarantee their right to the land.
President Jefferson's developed plans for removing the Natives to west lands on Mississippi were carried out by the later presidents that came right after him, what in fact caused the Indian tribes great sufferings and thousands of deaths and losses, as in the Trail of Tears.