Answer:
The effect of Fx on hepatic stearoyl-coenzyme A desaturase-1 (SCD1), a rate-limiting enzyme that catalyzes the biosynthesis of monounsaturated fatty acids from saturated fatty acids, has been studied in obese mouse models of hyperleptinemia (KK-A(y)) and leptin-deficiency (ob/ob). In KK-A(y) mice fed a diet containing 0.2% Fx for 2 weeks, SCD1 mRNA and protein expression were reduced in the liver with a concomitant decrease in serum leptin levels. In contrast, the suppressive effects of Fx on hepatic SCD1 and body weight gain were not observed in leptin-deficient ob/ob mice. These findings support the hypothesis that Fx down-regulates SCD1 expression and alters fatty acid composition of the liver through regulation of leptin signaling (Beppu et al., 2013).
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