Question

The toxin produced by the intestinal bacterium Vibrio cholerae induces excessive diarrhea by stimulating the excretion of NaCl and large amounts of water into the intestine. The mechanism by which cholera toxin acts is ADP ribosylation of: a. the GTP-bound form of Gai, locking it in the active conformation. b. the GDP-bound form of Gas, locking it in the inactive conformation. c. the GTP-bound form of Gas, locking it in the active conformation. d. Gaq, inhibiting its GTPase activity. e. Gai, decreasing its affinity for GDP.

Answer 1

c. the GTP-bound form of Gas, locking it in the active conformation.

Step-by-step explanation:

The reason is that the toxin created by the enteric intestinal bacterium Vibro cholerae triggers an exorbitant amount of diarrhea by inducing the excretion of NaCl and enormous amounts of water into the bowel. The mechanism by that epidemic cholera toxin acts is ADP ribosylation of the Gs alpha monetary unit. This implies that G
`\alpha`s macromolecule protein exploits NAD, therefore protecting it within the active conformation.