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If the frequency of the disorder in the population is 0.0070, what is the percentage of heterozygous carriers

User Immy
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1 Answer

4 votes

Answer:

15.322 %

Step-by-step explanation:

Supposing that this is a recessive disorder and the population is in Hardy-Weinberg equilibrium:

p² + 2pq + q² = 1, where

1- the genotypic frequency of the homo-zygous dominant allele is p²,

2- the genotypic frequency homo-zygous recessive allele is q², and

3- the genotypic frequency heterozygous allele is 2pq

Therefore:

q² = 0.007 >> q = √ 0.007 = 0,0836

p = 1 - q = 1 - 0,0836 = 0.9164

2pq = 2 x 0.9164 x 0,0836 = 0.15322 (or 15.322 %)

User Simon Featherstone
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