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Why and how were the Ottomans and Safavids fierce rivals?

User Figidon
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The two states were the greatest powers of West Asia, and the rivalry was further fueled by dogmatic differences: the Ottomans were Sunnis, while the Safavids were staunchly Shia Muslims of the Qizilbash sect, and seen as heretics by the Ottomans.
User Aravinthan K
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