Answer: -4x-34y-32
(I think this is right but I am not completely sure... if its not I am sorry :/ )
Explanation:
First Way:
48 (1/4x - 1/3y - 2/6x - 3/8y - 2/3)
48[(6/24x-8/24x)-(8/24y+9/24y)-2/3]
48(-2/24x-17/24y-2/3)
48(-1/12x-17/24y-2/3)
-4x-34y-32
Second Way:
48 (1/4x - 1/3y - 2/6x - 3/8y - 2/3)
12x-16y-16x-18y-32
-4x-34y-32