Question

During G2 the Wee1 protein phosphorylates tyrosine-15 of the Cdc2 protein kinase, thus inactivating it. Only once dephosphorylation occurs and Cdc2 becomes active carn the cell pass from G2 into M and proceed to cell division. Can you think of a reason why the Wee1 protein was named as such?

Answer 1

cells can't fully grow in Wee1 mutants

Step-by-step explanation:

The G2 phase is a period where cell growth and proteins are synthesized to prepare for cell division. The Wee1 protein is a dosage-dependent inhibitor of mitosis. Moreover, the cyclin-dependent kinase 2 (cdc2) is a protein involved in the regulation of the cell cycle which phosphorylates serine residues in Wee1. However, in Wee1 mutants, Cdc2 is not inactivated (phosphorylated). This change causes cells to enter M phase prematurely, thereby producing "wee" mutant cells.